Ī pathway for taurine biosynthesis from serine and sulfate is reported in microalgae, developing chicken embryos, and chick liver. Hypotaurine is then oxidized to taurine as described above. ![]() The cystathionine is then converted to hypotaurine by the sequential action of three enzymes: cystathionine gamma-lyase, cysteine dioxygenase, and cysteine sulfinic acid decarboxylase. Taurine is also produced by the transsulfuration pathway, which converts homocysteine into cystathionine. Hypotaurine is enzymatically oxidized to yield taurine by hypotaurine dehydrogenase. Cysteine sulfinic acid, in turn, is decarboxylated by sulfinoalanine decarboxylase to form hypotaurine. In this pathway, cysteine is first oxidized to its sulfinic acid, catalyzed by the enzyme cysteine dioxygenase. Mammalian taurine synthesis occurs in the pancreas via the cysteine sulfinic acid pathway. Taurine is naturally derived from cysteine. In the laboratory, taurine can be produced by alkylation of ammonia with bromoethanesulfonate salts. Most of these enterprises employ the ethanolamine method to produce a total annual production of about 3,000 tonnes. As of 2010, China alone has more than 40 manufacturers of taurine. In 1993, about 5,000–6,000 tonnes of taurine were produced for commercial purposes: 50% for pet food and 50% in pharmaceutical applications. A direct approach involves the reaction of aziridine with sulfurous acid. ![]() Synthetic taurine is obtained by the ammonolysis of isethionic acid (2-hydroxyethanesulfonic acid), which in turn is obtained from the reaction of ethylene oxide with aqueous sodium bisulfite. The sulfonic acid has a low p K a ensuring that it is fully ionized to the sulfonate at the pHs found in the intestinal tract. Taurine exists as a zwitterion H 3N +CH 2CH 2SO − 3, as verified by X-ray crystallography. It is an unusual example of a naturally occurring sulfonic acid.Ĭhemical and biochemical features Taurine concentrations in land plants are very low or undetectable, but up to 1000 nmol/g wet weight have been found in algae. It is essential for cardiovascular function, and development and function of skeletal muscle, the retina, and the central nervous system. It has many biological roles, such as conjugation of bile acids, antioxidation, osmoregulation, membrane stabilization, and modulation of calcium signaling. ![]() It was discovered in human bile in 1846 by Edmund Ronalds. It is named after Latin taurus ( cognate to Ancient Greek ταῦρος, taûros) meaning bull or ox, as it was first isolated from ox bile in 1827 by German scientists Friedrich Tiedemann and Leopold Gmelin. It is a major constituent of bile and can be found in the large intestine, and accounts for up to 0.1% of total human body weight. Taurine ( / ˈ t ɔː r iː n/), or 2-aminoethanesulfonic acid, is a non-proteinogenic amino sulfonic acid that is widely-distributed in animal tissues.
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![]() Proceedings of the 2015 ACM Conference on Innovation and Technology in Computer Science Education. "Thonny, a Python IDE for learning programming". Proceedings of the 15th Koli Calling Conference on Computing Education Research. "Introducing Thonny, a Python IDE for learning programming". List of integrated development environments for Python programming language.Since June 2017 it has been included by default in the Raspberry Pi's official operating system distribution Raspberry Pi OS. It has been a recommended tool in several programming MOOCs. Thonny has received favorable reviews from Python and computer science education communities. It can be installed via the operating-system package manager on Debian, Raspberry Pi, Ubuntu, and Fedora. It is available as a binary bundle including the recent Python interpreter or pip-installable package. The program works on Windows, macOS and Linux. Possibility to log user actions for replaying or analyzing the programming process.Support for running and managing files on a remote machine via SSH.Variables and memory can be explained either by using simplified model (name → value) or by using more realistic model (name → address/id → value).Separate windows for executing function calls (for explaining local variables and call stack).Stepping through evaluation of the expressions (expressions get replaced by their values).It supports different ways of stepping through code, step-by-step expression evaluation, detailed visualization of the call stack and a mode for explaining the concepts of references and heap. ![]() ![]() It was created by Aivar Annamaa, an Estonian programmer. Thonny ( / ˈ θ ɒ n i/ THON-ee) is an integrated development environment for Python that is designed for beginners. ![]() Using these 2 methods and the bonus method I was able to get extra 15 GB of space on my Mac. Try to delete these ones, which are not being used anymore. You'll see many archived deployed application, most probably you don't need all of them. daniel) -> Library -> Developer -> Xcode -> Archives. Macintosh) -> Users -> YOUR_USERNAME (e.g. ![]() You should see devices only from the newest version (here 13.2.3) like the screenshot below shows.Īs a bonus which is slightly less relevant to this question, but still free's some space. To be sure that everything is fine check it again by running xcrun simctl list devices. Many of them might be unavailable, therefore delete them by running xcrun simctl delete unavailable. The highest number (here 13.2.3) of the iOS version indicates that it's newer.Īfter this list your devices in Terminal by running xcrun simctl list devices. Leave there, the newest one, as of today this is 13.2.3 (17B111), but in future it'll change. Macintosh) -> Users -> YOUR_USERNAME ( daniel) -> Library -> Developer -> Xcode -> iOS Device Support. Old device simulators located at YOUR_MAC_NAME (e.g. Basically, there are 2 issues, which if you check them out & solve both - in 99% it should fix this issue: Some people try to fix it using one way, some the second. dmg file(s) here: ~/Library/Caches/.Xcode/Downloads Helping Xcode "forget" about runtimes and prevent from re-installing them - delete. To delete devices go here: ~/Library/Developer/CoreSimulator/Devices You will find them here: /Library/Developer/CoreSimulator/Profiles/Runtimes `xcrun simctl help` to explore **more** commands Original Answer `xcrun simctl get_app_container booted ` to find the app container (where identifier is like **) test.mp4` to upload photo or video file (for photos app) `xcrun simctl openurl booted ` to open URL in simulator screen.png` to make screenshot of simulator `xcrun simctl io booted recordVideo - type=mp4. Project, especially and for making XcodeInstall C extension free.- `xcrun simctl boot ` to launch (multiple) simulators Additionally, many thanks to everyone who has contributed to this This downloading script which has been used for some inspiration, also thisįor doing the installation. Thanks to the original (and best) author. But it still won't work if your Xcodes are not located under /Applications folder. ![]() To workaround the Spotlight limitation, XcodeInstall searches /Applications folder to locate Xcodes when Spotlight is disabled on the machine, or when Spotlight query for Xcode does not return any results. Indexing is happening, it might show inaccurate results and it will not be able to see installed XcodeInstall normally relies on the Spotlight index to locate installed versions of Xcode. ![]() Unfortunately, Xcode will load third-party plugins even in that situation, which leads XcodeInstall automatically installs additional components so that it is immediately usable from theĬommandline. Unfortunately, the installation size of Xcodes downloaded will be bigger than when downloading via the Mac App Store, see #10 and feel free to dupe the radar. Please authenticate to install iOS 8.4 Simulator. $ xcversion simulators -install='iOS 8.4' ![]() After killing Pontiff Sulyvahn, speak to Yuria at the Firelink Shrine.Don't attack anything in that area until you have progressed past step 8 (wedding)). (NOTE: Even after Anri leaves, the pilgrim/assassin may still be there disguised as one of the statues. DO NOT kill the pilgrim/assassin in the corner of the room disguised as a statue. Find Anri at the Church of Yorksha fire.If Horace is still alive and you inform Anri of his whereabouts in Smouldering Lake, Anri will later be found dead. If you killed Horace beforehand, choose dialogue option "Tell Anri of Smouldering Lake", which will have Anri set up a gravestone for Horace.Find Anri on the path near the wooden bridge before the High Lord Wolnir boss.To find the cave, hug the right wall when entering the lake.Enter the Smouldering Lake and kill Horace in the cave.Never tell Anri of Horace's whereabouts.Find Anri in the Catacombs of Carthus in a hallway next to the first rolling skeleton ball.Speak to them again at the Firelink Shrine after killing the Deacons of the Deep.Find Anri of Astora at the Halfway Fortress bonfire.So long as you DO NOT cure the dark sigil via Firekeeper. This gives you your human appearance whilst keeping your dark sigils. Note: You can "cure" your hollowing via Purging Stone. You should receive 5 dark sigils from him. ![]() The Purging stone and Velka Statue are safe to use, however. Also NEVER cure your Hollowing by talking with the Firekeeper after obtaining Soul of the Firekeeper. This will cause a premature ending to the questline. Doing this will cause the door to the catacombs to open, and upon entering, kills off Yoel. Must be done before killing the Abyss Watchers.
The vita-capsules concentrated with fresh vitamin C derivatives deliver bursts of radiance to your face. 70 green tangerine extract, plus pure essential oils, this wonderworking serum helps combat uneven skin tone and signs of aging including dark spots and fine lines. Goodal's Vita C Serum contains 7 natural plant-based ingredients that have been proven to have calming effects (Rosemary, Chamomile, Green tea, Licorice root, Centella, etc.). ![]() Tangerine Extract (70%), Butylene Glycol, Niacinamide, Dipropylene Glycol, Methylgluceth-20, Purified Water, 1,2-Hexanediol, Glycereth-26, Arbutin, Irish Moss Extract, Candy Sorghum Extract, Hydrolyzed Jojoba Ester, Sodium Hyaluronate, Bergamot Oil, Indian Mulberry Flower Extract, Holy Basil Leaf Extract, Indian Mulberry Leaf Extract, Turmeric Root Extract, True Coral Extract, Lavender Oil, Lemon Peel Oil, Ylang-Ylang Flower Oil, Orange Peel Oil, Eucalyptus Leaf Extract, Licorice Root Extract, Chamomile Flower Extract, Green Tea Extract, Centella Asiatica Extract, Rosemary Leaf Extract, Rhododendron Root Extract, Centella Asiatica Leaf Extract, Ammonium Acryloyldimethyl Taurate/Vpicopolymer, Panthenol, Choles-24, Tromethamine, Ethylhexylglycerin, Allantoin, Tocopheryl Acetate, Adenosine, Sodium Phytate, Ascorbyl Glucoside, Dipotassium Glycyrrhizate, Glycerin, Madecassoside, Maltodextrin, Saccharide Hydrolysate, Tocopherol, Asiaticoside, Carbomer, Xanthan Gum, Limonene, Linalool HOW TO USEĪpply an appropriate amount of Green Tangerine Vita C Dark Spot Serum evenly over face, avoiding the eye and lip areas. Description Say goodbye to dark spots, start seeing visible results in just two weeks. It contains 70% Jeju Green Tangerine Extract to add vitality to skin. ![]() In a consumer test of users with a variety of skin types, in just 2 weeks, 95% of users felt their skin was brighter and clearer after using this vitamin C serum regularly.įormulated without any artificial fragrances, animal products, mineral oils, essential oils, or silicone.Goodal Green Tangerine Vita C Dark Spot Care Serum helps to reduce hyperpigmentation and diminish the look of freckles and dark spots. This serum has a gel-like texture and is transparent, lightweight, absorbing quickly with no stickiness after application. This non-irritating formula also contains niacinamide and arbutin to further brighten, centella asiatica and green tea extracts to calm, and sodium hyaluronate to deeply hydrate. Powered by this fruit, our formula improves dark spots and post-acne hyperpigmentation while tackling the formation of new ones that have yet to surface. Two weeks is all you need to start seeing noticeable results of brighter, clearer skin with this vitamin C serum. Goodal Green Tangerine Vita C Dark Spot Serum Plus ingredients explained: Citrus Tangerina (Tangerine) Extract (70), Butylene Glycol, 1,2-Hexanediol, Dipropylene Glycol, Methyl Gluceth-20, Water, Glycereth-26, Niacinamide, Arbutin, Chondrus Crispus Extract, Saccharum Officinarum (Sugarcane) Extract, Hydrolyzed Jojoba Esters, Sodium Hyaluronate. Vitamin C helps fade dark spots and hyperpigmentation. Green tangerines contain up to 10x more vitamin C than their mature counterparts! They’re cold-pressed to ensure maximum nutrients are retained in the process. ![]() ![]() A fast favorite, this gel-like serum is packed with brightening and skin tone-evening benefits from 70% green tangerine extract, which is potent in natural vitamin C derivatives. ![]() If you do make improvements you think others could use, please share in the comments, or contact me so I can update the library here on the site. As with all Corona code I post on this site, the library is free to download, free to use, and you are free to modify it as you see fit. I hope that my fellow Corona developers will find this unofficial library update to be useful. For example, the following code would pause all active timers with the tag “myTag”. You can pause, resume, or cancel all timers with a specific tag by passing the tag as a parameter.You can pause, resume, or cancel all active timers (unless they have their exclude parameter set to true) by calling timer.pause(), timer.resume(), or timer.cancel() with no arguments.timer.pause(), timer.resume(), and timer.cancel() still work as before, but with the following new features:.Timer.performWithDelay(1000, myFunction, 1, "myTag", true) As an example, the following code would create a timer with the tag “myTag” that is excluded from non-specific pause, resume, or cancel calls:. ![]() These new arguments can be added in any order to the end of any existing timer.performWithDelay() call.Timers that are mission-critical and should always run should have their exclude parameter set to true. exclude is a boolean (true/false) parameter that, when set to true, excludes the timer from being impacted by timer.pause(), timer.resume(), or timer.cancel() calls that do not specifically target it by passing the timer’s handle or tag.tag is a string that appends a tag to the created timer that can be used to pause, resume, or cancel all timers with the same tag at once.timer.performWithDelay() now accepts two new optional function arguments: tag and exclude:.But you also gain access to these new features: Note that your existing code will continue to work – version 2.0 is fully backwards-compatible with the current official timer APIs. Require the library in your project by adding this one line of code, preferably near the top of your a:īy taking those steps, you have updated Corona’s built-in timer library to version 2.0.Download a and place it in your project’s root directory.Updating the timer library to “timer 2.0” in your Corona project is as simple as these two steps: I still think that’s worth doing, and if you’re reading this, then you should definitely do that! However, part of what I love about Corona is how we developers can roll our own solutions to these sorts of problems while we wait for Corona Labs to add new features or fix bugs – so I decided to do just that and “fix” the timer library to enable those requested features. In my comment on that forum post, I suggested that the original poster vote up a Corona SDK feature request for the timer library to receive an update akin to the “Transition 2.0” update from a few years ago, so that we would have the ability to pause/resume/cancel all active timers at once, or to pause/resume/cancel a subset of active timers by tagging them. Under the current system, it’s very easy to accidentally leave a timer running when you would rather pause or cancel all your timers, or at least a number of them. Now the Corona SDK already gives us methods for pausing, resuming, or even canceling active timers, but those methods are somewhat restricted in that you can only cancel one timer at a time, and you must refer to the timer by it’s handle to do so. I recently commented on a post on the Corona Labs forum from a developer who was having a hard time with timers that were not canceled when a scene was changed. ![]() Curtis Mayfield, who had been part of the Chicago soul group The Impressions, penned the songs and conceived the musical score. In retrospect, the songs and music are considered the film's strength by contemporary reviewers. Michael Peters, who won a Tony for his choreography for Dreamgirls, plays an outrageous rhythm-and-blues artist along the lines of Screamin' Jay Hawkins. Rogers went against this expectation and instead wore a tuxedo and spoke directly to his audiences no matter their race. They had to perform in pairs or play characters, including those in blackface and garish clothes. When Rogers began his career, black comics were still performing using heavy slang and vernacular and could not directly address a white audience. Comedian Timmie Rogers appeared as the emcee at the Shan-Doo Club. Comic actor Don Bexley, best known for his role as Bubba on Sanford and Son, played the bawdy emcee during the amateur contest sequence. She was cast in several notable films and Broadway productions of the 1970s and 1980s, including Francis Ford Coppola's The Cotton Club (1984) and Gardens of Stone (1987).Īfrican American audiences likely recognized a few familiar faces in cameos and bit roles sprinkled throughout Sparkle. McKee benefitted the most from Sparkle as reviewers singled out her vibrant performance, and she became an idol for a generation of African American girls. Levi is portrayed by Dorian Harewood, who went on to a successful career as a character actor in film and television, including Stanley Kubrick's Full Metal Jacket (1987). ![]() ![]() Stix is played by Philip Michael Thomas, who would become a major television star as Ricardo Tubbs on Miami Vice. Sparkle was her second feature film, preceding her breakthrough performance in Fame by four years. Cara was only 16 when she costarred in Sparkle, but she had already been performing on Broadway and on television for nine years. Sparkle boasts a notable cast of newcomers, who would go on to wider fame, as well as bit players who were veterans of black entertainment circuits from an earlier era. Dwan Smith costars as Delores, who becomes more interested in racial issues and politics than singing, while a teenage Irene Cara plays the title character who is destined to be the biggest star. Lonette McKee stars as Sister Williams, a beautiful, self-assured woman who falls under the sway of a smooth-talking rogue who leads her into drugs. They quickly become a sensation in the local club scene, but the sisters display disparate personalities, creating a stumbling block to fame and fortune. The trio are managed by two young men from the neighborhood, Stix and Levi. In Sparkle, three Harlem sisters-Sister, Delores and Sparkle Williams-form a singing group in dubbed Sister & the Sisters. Along the way, a diva emerges from the group while the others fall prey to the temptations of men and drugs. The essential ingredients for such a tale includes their management by a Svengali-like male, who must contend with clashing egos and a merciless music business. The success stories of these all-female singing groups were told and retold in publicity, biographies and promotional materials until an archetypal tale emerged that seemed to describe the path to success for all of them. But, before Dreamgirls, there was Sparkle, a 1976 musical starring Irene Cara, Lonette McKee and Dwan Smith, which was a precursor and maybe influence on the more well-known play and film.īoth Dreamgirls and Sparkle follow a dramatic arc familiar to a generation who grew up with the actual girl groups of the 1960s, specifically the Supremes. Most would identify this as the plot to the 1981 Broadway musical Dreamgirls and its 2006 film adaptation. As they work their way toward success, they find the road to stardom is paved with heartache, temptations and disappointments. In the late 1950s, three talented female singers from the inner city form a girl group. ![]() ![]() Cardi followed up, “It’s a metaphorical quote,” suggesting that achievement and constipation are just two of many possible interpretations of the song and that poop probably wasn’t actually on Cardi’s mind when she wrote the tune.Įlsewhere during the show, Cardi and Fallon faced off in the “Mimic Challenge,” so check out clips from the show above and below. Yeah.”Ī stunned Fallon then offered his own take, suggesting the phrase could be about reaching a certain level of success and then maintaining it. ![]() I guess, whatever.’ So, have you ever taken a poop, right, and it don’t come out? It’s just up and it’s stuck. After the song came out, I thought it was a Georgia thing, but then people were like, ‘We say that in New Orleans,’ ‘We say that in Florida.’ I’m like, ‘OK, man, listen. Well, Cardi guested on The Tonight Show yesterday and she told Fallon that “Up” is also about the body, albeit in a markedly different way than “WAP” is.įallon asked about Offset’s role in the lyric and Cardi answered, “He says that a lot. When it comes to Cardi’s new single “ Up,” though, the lyrics are a bit less transparent and more open to interpretation. Cardi brings it in her verse, rapping, Put a ribbon on me, I been actin’ brand new/ I ain’t smokin’ on no za’, lil’ bch, I’m smokin’ on you/ Put your bestie in a pack and now I. When it comes to Cardi B and Megan Thee Stallion’s “WAP,” it’s immediately obvious what the song is about. Cardi B Up lyrics explained: Twitter fans confused by it’s stuck line Kate Fowler Fri 5 February 2021 10:20, UK Cardi B’s lyrics always have fans feeling some type of way, and Up. 42K 1.3M views 1 year ago CardiB JimmyFallon FallonTonight Cardi B talks about how she and Megan Thee Stallion collaborated to write WAP, filming music videos during the pandemic and her. Kelly Clarksons newest song features a one-of-a-kind guest artist: Steve Martin The GRAMMY-winning pop star teamed up with Martin, known to be a talented banjo player, for her most recent single. Someone grabbed this pic of her and Algee from her Instagram Story. They’re all pretty close in age, so it makes sense that they would get along. Rue pursues a new dangerous business venture as she sinks deep into her addiction, largely caused by her guilt-ridden new friend Eliott. The cast of Euphoria seems super tight, which is the cutest thing ever. She has to figure out how to navigate the world.” She and her costars are super adorable together. Like, ‘Do I send them?’ It’s like a form of currency. Euphoria (TV Series 2019 ) Sydney Sweeney as Cassie Howard. Elsewhere, Nate Jacobs (Jacob Elordi) looks set to pursue a dramatic love triangle with ex-girlfriend Maddy Perez (Alexa Demie) and her troubled best friend Cassie Howard (Sydney Sweeney). There’s this whole story line with nudes that many teenage girls deal with. “ She always falls in love with every boyfriend that she has and gets a sexual reputation that she doesn’t know how to get out of. “Cassie hasn’t really quite figured out who she is yet,” Sydney told InStyle recently. “Nudes are the currency of love,” as Rue would say. ![]() ![]() He texts her to apologize after the fact and ask for nudes, and she sends them. While talking to her about his football problems, she tries to hook up with him and he slut-shames her for not respecting the fact that he’s trying to have a conversation with her. 14 Play trailer 0:31 27 Videos 99+ Photos Drama A look at life for a group of high school students as they grapple with issues of drugs, sex, and violence. One fan-favorite character will not be returning for the new season. Check out more streaming guides in Vague Visages’ Know the Cast section. This info article contains minor spoilers and character details for Sam Levinson’s HBO Max series. In the second episode, summer is over and Chris comes home from college to visit Cassie. Hough on JanuThe Euphoria cast features Zendaya, Jacob Elordi and Sydney Sweeney. Get to Know ‘Euphoria’ Star Hunter Schafer? Cassie Howards Girly Innocence Image Source: HBO Similar to her friend Maddy, yet not quite in the same way, Cassie (played by Sydney Sweeney) wears revealing pieces, but hers are often in. ![]() Microsoft Excel Beginner or Advanced User, and want to learn more? Your tutor is ready and waiting. Microsoft Excel has the basic features of all spreadsheets using a grid of cells arranged in numbered rows and letter-named columns to organize data manipulations like arithmetic operations. If we can help you with private Microsoft Excel tutoring, please feel free to fill out the sign up form below or on the right sidebar.Microsoft Excel has almost completely replaced Lotus 1-2-3 as the industry standard for spreadsheets.
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